In a further experiment, the investigators fed untrained mice a substance called AICAR, a synthetic version of AMP that triggers the AMPK switch directly. 在进一步的实验中,研究人员给未经训练的老鼠喂养一种物质叫AICAR,一个AMP的合成版可以直接触发AMPK转化。
Conclusion: AICAR, metformin and pioglitazone can decrease the damage of HUVEC induced by PA, possibly through activating AMPK. 结论:AICAR、Met和PGZ可能通过激活AMPK,显著减轻PA诱导的HUVEC的损伤。