Antagonists tend to be small molecules that bind irreversibly to the receptor preventing its normal function, while agonists may be small or large molecules ( e.g. peptide or protein hormones). 抑制剂一般是小分子,他们不可逆转地结合在受体上阻碍其正常功能,而兴奋剂可以是小或大分子。
TLR3 agonists, as immunoadjuvant, have been applied for adjuvant immunotherapy of some tumors. TLR3激动剂作为免疫佐剂已应用到某些肿瘤的辅助性免疫治疗。
Our TLR9 agonists are based on immunostimulatory sequences, or ISS, which are short DNA sequences that enhance the ability of the immune system to fight disease and control chronic inflammation. 我们的TLR9显效药是基于免疫共刺激序列(ISS)的。ISS是一短DNA序列,它提高免疫系统能力来对抗疾病并控制慢性炎症。
Application of mouse tail artery for the study of alpha adrenoceptor agonists and antagonists and calcium antagonists 小鼠尾动脉条应用于α肾上腺素受体激动剂、拮抗剂和钙拮抗剂的研究
Adverse effects associated with short-term gonadorelin agonists are common, but are rarely serious enough to require drug withdrawal. 短期促性腺激素释放因子治疗相关的副作用是常见的,但严重到足以停药的程度是罕见的。
So, Spiegelman and colleagues undertook studies to determine whether PPAR agonists might be useful as adjuvant therapy with currently used chemotherapeutics. 因此,Spiegelman和他的同事着手研究以确定PPAR激动剂是否可以作为目前化疗的有用的辅助治疗。
The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas. 目前的研究目的是评估使用多巴胺激动剂治疗的泌乳素瘤病人瓣膜性心脏病的患病率。
So I do not have a non-steroidal anti-inflammatory drugs Characteristics, nor opioid receptor agonists. 所以不具有非甾体抗炎药的特性,亦非阿片受体激动剂。
Many reports have shown anti-proliferative effects of PPAR agonists, suggesting their utility in cancer therapy. 很多报告显示PPAR激动剂有抗增值的作用,暗示了其在肿瘤治疗中的有用性。
Efficacy Analysis of Inhaled Glucocorticoids and β_2-Receptor Agonists in Mild Persistent Asthmatics 吸入糖皮质激素联合β2-受体激动剂治疗中度持续性哮喘的疗效分析
The establishment of yeast-based screen platform for PPAR agonists and antagonists. 基于酵母水平PPAR激动剂和抑制剂筛选模型的建立;
CONCLUSIONS Weight reduction with GLP-1 receptor agonists was associated with a shift toward a more favorable cardiovascular risk profile. 结论:GLP-1受体激动剂治疗后的体重减轻与心血管危险因素谱向更有益的方向转变有关。
Efficacy and Safety of Pramipexole Use Switched from Various Dopamine Receptor Agonists 多种多巴胺受体激动剂转换为普拉克索的疗效和安全性研究
Conclusion Visual hallucination is a common non-motor symptom among patients with PD, and cognitive function, disease severity and usage of dopamine agonists may be related to visual hallucination. 结论视幻觉是PD患者常见的一种非运动性症状,认知功能、病情严重程度、多巴胺激动剂的使用可能与视幻觉的发生有关。
Conclusions In this study, use of the dopamine agonists pergolide and cabergoline was associated with an increased risk of newly diagnosed cardiac-valve regurgitation. 结论:研究发现使用多巴胺受体激动剂培高利特和卡麦角林可增加新发生的心脏瓣膜返流的风险。
Similar results were observed in human platelet-rich plasma stimulated by agonists. 类似的结果也发生在人类富含血小板之血浆的凝集作用。
Determination and Analysis of the β-Adrenergic Agonists Drug Residues in Dongguan Livestock 东莞市生猪β-肾上腺受体激动剂残留的检测与分析
Influence of Intra-Caudate-Putamen Injection of μ-or δ-Opioid Recptor Agonists on Operant Conditioning Reflex in Rats 大鼠尾壳核内注射μ或δ型阿片受体激动剂对操作式条件反射的影响
Effects of A_1 adenosine receptor agonists on RGS_4 in hypoxia-induced right ventricular hypertrophy in rats 腺苷A1受体激动剂拮抗大鼠慢性低氧所致右心室肥厚的实验研究
The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. 本发明涉及新化合物,它们是阿片样物质受体的拮抗剂或反向激动剂。
Retinoid X receptor Agonists Inhibit High-Glucose-Induced Oxidative Stress in Human Endothelial Cells 视黄醇类X受体激动剂抑制高糖诱导内皮细胞氧化应激
Expression of Cannabinoid receptor 2 in the CNS and pharmacology of its agonists ***CB2受体在中枢神经系统的分布及其激动剂的药理作用
In all flexion activities, symmetrical or asymmetrical sternocleidomastoids were the major flexor muscles, and they had to balance the mechanics of the neck as agonists, synergists, or antagonists. 在所有的前屈肌中,对称性的和不对称的胸锁乳突肌是主要的前屈肌,并且,他们在颈椎的运动中,承担着主动肌、平衡肌和拮抗肌的作用。
In a voluntary cervical motion, the neuromotor control exercised by the central nervous system determines the time, intensity, and a nature of excitation of agonists and antagonist muscles. 在颈椎主动运动的过程中,由中枢神经所支配的神经运动取决于主动肌和拮抗肌刺激反应的时间和紧张程度。
Role of Peripheral Cannabinoid Receptor 2 and Endogenous Agonists in the Modulation of Pruritus 外周内源性***受体激动剂及其受体2亚型参与搔痒调节的研究
Objective: Treatment with ergot-derived dopamine agonists, pergolide, and cabergoline has been associated with an increased frequency of valvular heart disease in Parkinson's disease. 目的:使用麦角衍生的多巴胺激动剂,已经证实帕金森病人使用培高利特和卡麦角林可能增加瓣膜心脏病。
Chronic inflammation is thought to play a key role in this pathogenic process and recent reports have suggested that PPAR-gamma agonists may have a beneficial effect in this regard. 慢性炎症可能在这一病理过程中发挥了重要作用,最近的有报道称PPAR-γ激动剂可能会抑制此过程。
What are the sedative effects of alpha 2 agonists? 2受体激动剂的镇静效果机理是什么?
Effect of Histamine H_3 Receptor Antagonists and Agonists on the Content of cAMP and CREB on Morphine Relapse Rats 组胺H3受体拮抗剂和激动剂对***复吸大鼠cAMP及CREB含量的影响
Agonists of PPAR, a member of the nuclear hormone receptor family of transcription factors, are widely used in the treatment of type II diabetes and are relatively non-toxic. PPAR激动剂,是细胞核激素受体家族转录因子的一个成员,被广泛用来治疗II型糖尿病,而且相对无毒。